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Marhamah Marhamah
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Journal : Media Penelitian dan Pengembangan Kesehatan

 1 
PENGUJIAN AKTIVITAS ANTIACNE NANOPARTIKEL KITOSAN – EKSTRAK KULIT BUAH MANGGIS (Garcinia mangostana) Rismana, Eriawan; Kusumaningrum, Susi; Bunga, Olivia; Nizar, Nizar; Marhamah, Marhamah
Media Penelitian dan Pengembangan Kesehatan Vol 24, No 1 Mar (2014)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

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Abstract

AbstrakUji aktivitas antiacne dari pasta dan bubuk nanopartikel kitosan – ekstrak kulit manggis telah diamati terhadap daya hambat pertumbuhan Propionibacterium acnes. Bahan pasta nanopartikel kitosan – ekstrak manggis dibuat melalui reaksi gelasi ionik dengan cara mencampurkan larutan kitosan 0,2 % (dalam asam asetat) dengan ekstrak etanol 70 %kulit buah manggis yang kemudian direaksikan dengan natrium tripolifosfat 0,1 %. Sedangkan bahan bubuk nanopartikel kitosan – ekstrak manggis diproduksi melalui metode freeze drying dari bahan pasta nanopartikel. Hasil pengujian antiacne dari bahan pasta dan bubuk nanopartikel kitosan – ekstrak manggis menunjukkan bahwa kedua bahan dapat menghambat pertumbuhan Propionibacterium acnes yang baik dengan konsentrasi terendah 0.15 %.Kata kunci : antiacne, pasta, kitosan, nanopartikel, ekstrak etanol 70 % kulit buah manggisAbstractThe antiacne activity of paste and powder of chitosan – Garcinia mangostana extract nanoparticles were observed that it’s against of Propionibacterium acnes. The paste of nanoparticles has been prepared by ionic gelation reaction by mixture 0.2 % chitosan solution in acetic acid with Garcinia mangostana 70 % ethanol extract and it’s continued byreaction process with 0.1 % sodium tripolyphosphate. Meanwhile the powder of nanoparticles was produced by freeze drying process of a paste of the nanoparticles. The results of antiacne activity of paste and powder of nanoparticles were showed that it’s could against Propionibacterium acnes with the lowest concentration about 0.15 %.Keywords : antiacnes, paste, chitosan, nanoparticles, Garcinia mangostana 70 % ethanol extract
Co-Authors Abzeni, Abzeni Allen Marga Retta, Allen Marga Aminudin, Muhammad Andinasari Andinasari, Andinasari Arista, Yeli edy susanto Eri Hartanto, Eri Eriawan Rismana Herawati Susilo Ibrohim Ibrohim Idah Rosidah Juwita Juwita, Juwita Lestaria N, Yunika Mardawati, Verani Ari Mimien Henie Irawati Misdalina Misdalina Mursalina, Ditya Nila Kesumawati Nizar Nizar Olivia Bunga p, olivia bunga Permatasari, Siti Widia R. Sapto Hendri Boedi Soesatyo ROHANA ROHANA Sarbullah, Sarbullah Seniasih, Ni Ketut STELLA STELLA Susi Kusumaningrum Sutrisno, Sutrisno Syifaul Fuada, Syifaul Syofianis, Syofianis Tona, Tona Wahyuni, Dedek Widyartati, Penta Wiranti, Sri Yuliana, Diah Yulianto Yulianto